Dans Puiggrós, Pablo Daniel

Research interests

My focus lies in the biophysics and physical chemistry of complex systems, achieved through modeling the structure, physical and chemical properties, interactions, transformations, and kinetics of molecules within biologically and biomedically relevant systems. I have contributed to the development of multiscale models and Hamiltonians for nucleic acids, from atomistic force fields and coarse-grained models to 3D/4D mesoscale models of chromatin, chromosomes, and whole nuclei. My expertise encompasses the structure, dynamics, flexibility, conformational sampling, sequence-dependent physical properties, and evolution of nucleic acids (DNA and RNA), including the effects of epigenetic modifications, non-canonical base pairings, and interactions with proteins and solvents.

Working area

My research spans the fields of computational chemistry, computational biophysics, structural bioinformatics, molecular modeling, and multiscale modeling.